The dead include two children and two women. The bus driver was also injured in the accident.
The injured have been shifted to the Tando Adam Hospital, police said.
Police has detained the driver and an investigation is underway.
The passenger bus had set off from Karachi for Sanghar.
The 2018 Boao Forum for Asia (BFA) annual conference is scheduled for April 8 to 11 in Boao, Hainan Province. The forum will be themed "An Open and Innovative Asia for a World of Greater Prosperity."
— The Daily Mail - People's Daily